N,N-Dimethylaniline → 2-bromo-N-(2,2,3,3,3-pentafluoropropyl)acetamide

Participants

Reaction Conditions

Reaction Steps

2,2,3,3,3-Pentafluoropropylamine (produced by Synquest) (389 g) was dissolved in ethyl acetate (1.56 L), and N,N-dimethylaniline (316 g) was added thereto. After cooling the mixture to −10° C., bromoacetyl bromide (500 g) was added dropwise thereto, and the resulting mixture was stirred at a temperature between 10° C. and 0° C. for 2 hours. The organic layer was sequentially washed with aqueous hydrochloric acid, aqueous sodium bicarbonate and with brine, and dried over anhydrous magnesium sulfate, followed by concentration under reduced pressure to obtain 2-bromo-N-(2,2,3,3,3-pentafluoropropyl)acetamide (678 g) as a white powder.

Provenance & Evidence