HCID 178467360, compound → HCID 178467359, compound

Participants

Reaction Steps

Thioacetic acid S-[2-({2-ethoxy-3-[2′-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carbonyl}amino)-4-methylpentyl]ester (80 mg, 0.1 mmol) was dissolved in MeOH (5 mL) and 1M NaOH (5 mL). The mixture was stirred for 1 hour with nitrogen gas bubbling through the solution. The reaction was quenched with acetic acid (5 mL) and the mixture evaporated to dryness. The residue was purified using reverse phase preparative HPLC to afford the title compound (540 μg). ESMS [M+H]+ calcd for C30H33N7O2S, 555.3. found 556.4.

Provenance & Evidence