Tetrahydrofuran → HCID 44358869, compound

Participants

Reaction Conditions

Reaction Steps

0.12 g of 5% Pd/C (50% wet) is added to a solution of the compound obtained in Step A (0.5 g) in a mixture of MeOH (6.5 mL)/THF (6.5 mL). The mixture is purged with nitrogen and then with hydrogen before being heated at 50° C. under atmospheric pressure during 1 hour. The suspension is then filtered over Celite and the filter is washed with a mixture of MeOH (5 mL)/THF (5 mL). The liquors are concentrated under reduced pressure to yield the title product in the form of a solid which is directly engaged in the following step without further purification.

Provenance & Evidence