HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → Agomelatine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 2-(7-Methoxynaphthalen-1-yl)ethan-1-amine hydrochloride | HCID 16050055 | — |
| Solvent | Water | HCID 962 | — |
| Product | Agomelatine | HCID 82148 | — |
Reaction Steps
In a reactor, 5 g of the compound obtained in Step C and 2 g of sodium acetate are introduced into ethanol. The mixture is stirred, 2.3 g of acetic anhydride are then added, the reaction mixture is heated to reflux and 20 ml of water are added. The reaction mixture is allowed to return to ambient temperature and the precipitate obtained is filtered off and washed with an ethanol/water 35/65 mixture to yield the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08212077B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-92b6f771319f45bcbea6a6f43a20e8f7 |
| Source note | uspto-grants-2012_07 |