Water → 3,5-Di-tert-butyl-4-hydroxybenzaldehyde

HRID 1511179Notes

Reaction equation

HRID 1511179 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([CH3:14])([CH3:13])[CH3:12])[C:6]=1[OH:15])([CH3:4])([CH3:3])[CH3:2].[CH2:16]1N2CN3CN(C2)CN1C3.[OH2:26]>C(O)(=O)C>[C:11]([C:7]1[CH:8]=[C:9]([CH:10]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[C:6]=1[OH:15])[CH:16]=[O:26])([CH3:14])([CH3:13])[CH3:12]

Participants

5

Reactant 3

HCID 962WaterHCID 4101HexamethylenetetramineHCID 314052,6-Di-tert-butylphenol

Product 1

HCID 732193,5-Di-tert-butyl-4-hydroxybenzaldehyde

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

2,6-di-tert-butylphenol was dissolved in glacial acetic acid. Subsequently, urotropin and water were added, and the reaction mixture heated at different temperatures for 5.5 hours. The precipitated product was filtered off and washed with water and methanol, and dried on a rotary evaporator. The particular reaction temperatures, yields and purities are shown in Table 5.

Workup

  1. temperaturethe reaction mixture heated at different temperatures for 5.5 hours
  2. filtrationThe precipitated product was filtered off
  3. washwashed with water and methanol
  4. customdried on a rotary evaporator
  5. customThe particular reaction temperatures
  6. customyields

Sources & evidence

ORD record
ord-3d35a91dcad54521b250ed3d6841fbad
Source dataset
uspto-grants-2012_07
Patent number
US08212081B2

Reaction notes

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