Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Methanol | HCID 887 | — |
| Edukt | Ammonium Chloride | HCID 25517 | — |
| Edukt | Sodium borohydride | HCID 4311764 | — |
| Edukt | 1-(4-Bromo-2-chlorophenyl)ethan-1-one | HCID 15560950 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Lösungsmittel | Ethyl Acetate | HCID 8857 | — |
| Produkt | 1-(4-Bromo-2-chlorophenyl)ethanol | HCID 20258128 | — |
Reaktionsschritte
To a stirring solution of 1-(4-bromo-2-chlorophenyl)ethanone (700 mg, 2998 μmol) in THF (20 mL) was added sodium borohydride (340 mg, 8994 μmol) and methanol (5 mL). Reaction suspension stirred overnight at 30° C. Reaction then partioned between EtOAc (50 mL) and sat NH4Cl (25 mL). Aqueous further extracted with EtOAc (2×25 mL). Combined organics dried over MgSO4, concentrated, then purified on silica (40 g) eluting with 10>40% EtOAc/hexanes. Product isolated as a colorless oil.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US08212041B2 |
|---|
| Quelldatensatz | uspto-grants-2012_07 |
|---|
| ORD ID | ord-d422b6f04af241ae8d062d7edde8d448 |
|---|
| Quellennotiz | uspto-grants-2012_07 |
|---|
