Ammonium Hydroxide → 6-Methoxy-3-methylisoquinolin-1(2H)-one

HRID 1511471ノート

反応式

HRID 1511471 の反応式
[C:1]([CH:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:14][CH3:15])[CH:12]=2)[C:7](=O)[O:6]C1=O)(=O)[CH3:2].[OH-].[NH4+:19]>>[CH3:15][O:14][C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:6])[NH:19][C:1]([CH3:2])=[CH:4]2

参加物

3

反応物 2

HCID 14923Ammonium HydroxideHCID 578931304-Acetyl-6-methoxy-1H-2-benzopyran-1,3(4H)-dione

生成物 1

HCID 123270606-Methoxy-3-methylisoquinolin-1(2H)-one収率 74%

実験手順

The cyclic anhydride of step 1 (405 mg; 1.73 mmol) was dissolved in aqueous ammonium hydroxide, and heated at reflux for 1.5 hours. The mixture was cooled to room temperature and the solid was filtered then dried overnight to give 270 mg (74%) of 6-methoxy-3-methylisoquinolin-1(2H)-one.

後処理

  1. temperatureheated
  2. temperatureat reflux for 1.5 hours
  3. filtrationthe solid was filtered
  4. customthen dried overnight

出典と根拠

ORDレコード
ord-4941a13f38e8426d85ad9bf28bc65ccd
出典データセット
uspto-grants-2012_07
特許番号
US08211897B2

反応ノート

読み込み中…