反应详情

The cyclic anhydride of step 1 (405 mg; 1.73 mmol) was dissolved in aqueous ammonium hydroxide, and heated at reflux for 1.5 hours. The mixture was cooled to room temperature and the solid was filtered then dried overnight to give 270 mg (74%) of 6-methoxy-3-methylisoquinolin-1(2H)-one.

1. temperatureheated
2. temperatureat reflux for 1.5 hours
3. filtrationthe solid was filtered
4. customthen dried overnight