反应详情

温度

0 °C

N-Boc-N-methylhydroxylamine (a) (0.74 g, 5 mmol) was dissolved in 10 ml DMF, treated with NaH (200 mg, 60% dispersion in mineral oil, 4.75 mmol), and stirred for 1 h under an argon atmosphere. The mixture was cooled to 0° C., treated with a solution of 4-bromo-butoxy)-tert-butyl-diphenyl-silane (b) (1.56 g, 4 mmol) in DMF (10 mL) and stirred at 0° C. for an additional 3 hours. The solvents were removed under reduced pressure, and the residue was dissolved in EtOAc (150 mL) and poured into a separatory funnel. The organic layer was washed with 0.1 M NaOH (5×50 mL), H2O (50 ml), 0.1 M KHSO4, and brine (50 ml) and the dried with MgSO4. After removal of the solvent, the residue was chromatographed on silicagel(Hexane:EtOAc 10:1) to yield 0.588 g (24%). The product was identified by electrospray mass spectrometry (ESI-MS)(MFE calculated 457.26; found 457.8)

1. stirringstirred at 0° C. for an additional 3 hours
2. customThe solvents were removed under reduced pressure
3. dissolutionthe residue was dissolved in EtOAc (150 mL)
4. additionpoured into a separatory funnel
5. washThe organic layer was washed with 0.1 M NaOH (5×50 mL), H2O (50 ml), 0.1 M KHSO4, and brine (50 ml)
6. dry with materialthe dried with MgSO4
7. customAfter removal of the solvent
8. customthe residue was chromatographed on silicagel(Hexane:EtOAc 10:1)
9. customto yield 0.588 g (24%)