反应详情

Sodium borohydride (0.14 g, 3.7 mmol) was added to a solution of N-(3-acetyl-benzo[b]thiophen-2-yl)-N-(4-fluoro-3-trifluoromethyl-benzyl)-ethanesulfonamide (0.268 g, 0.582 mmol) in ethanol (10 mL), and the resulting mixture was stirred at room temperature for 3 h. The solvent was evaporated, the residue partitioned between dichloromethane and water, the organic layer separated, dried over sodium sulfate, filtered, and the solvent evaporated in vacuo to yield a residue. The residue was purified by flash column chromatography (SiO2), eluting with an ethyl acetate-heptane (10-40%) gradient to yield N-(4-fluoro-3-trifluoromethyl-benzyl)-N-[3-(1-hydroxy-ethyl)-benzo[b]thiophen-2-yl]-ethanesulfonamide as a colorless solid.

1. customThe solvent was evaporated
2. customthe residue partitioned between dichloromethane and water
3. customthe organic layer separated
4. dry with materialdried over sodium sulfate
5. filtrationfiltered
6. customthe solvent evaporated in vacuo
7. customto yield a residue
8. customThe residue was purified by flash column chromatography (SiO2)
9. washeluting with an ethyl acetate-heptane (10-40%) gradient