Potassium Carbonate → HCID 131729804, compound

Participants

Reaction Conditions

Reaction Steps

Compound 1 (0.8 g, 3.19 mmol) was dissolved in dry DMF (30 ml). Dried potassium carbonate (1.32 g, 9.57 mmol) was added and the mixture was deaerated with argon. Tert-butyl bromoacetate (0.71 ml, 4.78 mmol) was added to the mixture and the reaction was stirred overnight at 70° C. The reaction mixture was cooled to room temperature and diluted with water (20 ml). The product was extracted with diethyl ether (3×50 ml) and dried over sodium sulphate. The product was purified by flash chromatography on silica gel using dichloromethane as an eluent. The yield was 1.1 g (96%). 1H NMR (CDCl3, 500 MHz): δ 7.66 (1H, d, J=8.5 Hz), 6.39 (1H, dd, J=8.5 Hz, 2.5 Hz), 6.34 (1H, d, J=2.5), 4.57 (2H, s), 3.79 (3H, s), 1.51 (9H, s).

Provenance & Evidence