4-Pentyn-1-ol → 3-Methyl-N-{[(pent-4-yn-1-yl)oxy]carbonyl}-L-valine

HRID 1511585Notes

Reaction equation

HRID 1511585 reaction equation
[CH3:1][C:2]([CH3:17])([CH3:16])[C@@H:3]([C:13]([OH:15])=[O:14])[NH:4][C:5]([O:7][CH2:8][CH2:9][CH2:10][CH:11]=[CH2:12])=[O:6].C(O)CCC#C>>[CH3:1][C:2]([CH3:17])([CH3:16])[C@@H:3]([C:13]([OH:15])=[O:14])[NH:4][C:5]([O:7][CH2:8][CH2:9][CH2:10][C:11]#[CH:12])=[O:6]

Participants

3

Reactant 2

HCID 793464-Pentyn-1-olHCID 453799283-Methyl-N-{[(pent-4-en-1-yl)oxy]carbonyl}-L-valine

Product 1

HCID 574311933-Methyl-N-{[(pent-4-yn-1-yl)oxy]carbonyl}-L-valine

Procedure

3-Methyl-N-[(pent-4-yn-1-yloxy)carbonyl]-L-valine was prepared according to the procedure for 3-methyl-N-[(pent-4-enyloxy)carbonyl]-L-valine by using pent-4-yn-1-ol instead of 4-pentenol. LRMS (ESI) m/z 242.2 [(M+H)+; calcd for C12H20NO4: 242.1].

Sources & evidence

ORD record
ord-f26067ee38fb4b27b54ec3fc5f49a7c4
Source dataset
uspto-grants-2012_07
Patent number
US08216999B2

Reaction notes

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