反应详情

2-Thiophene aldehyde (62.8 g) and 74.6 g of aminoacetaldehyde diethylacetal were dissolved in 200 mL of toluene and heated to reflux for 6 hours together with dehydration using a Dean-Stark trap. After confirming that a theoretical amount of water was separated, the solvent was evaporated therefrom in vacuo. The concentrated liquid was purified by a vacuum distillation to give 119 g of the objective compound.

1. temperatureheated
2. temperatureto reflux for 6 hours together with dehydration
3. customwas separated
4. customthe solvent was evaporated
5. distillationThe concentrated liquid was purified by a vacuum distillation