Water → 2,2-Diethoxy-N-(thiophen-2-ylmethylene)ethaneamine

HRID 1511594노트

반응식

HRID 1511594 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=O.[CH2:8]([O:10][CH:11]([O:14][CH2:15][CH3:16])[CH2:12][NH2:13])[CH3:9].O>C1(C)C=CC=CC=1>[CH2:8]([O:10][CH:11]([O:14][CH2:15][CH3:16])[CH2:12][N:13]=[CH:6][C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)[CH3:9]

참가 물질

5

반응물 3

HCID 962WaterHCID 73642-ThiophenecarboxaldehydeHCID 695242,2-Diethoxyethylamine

생성물 1

HCID 218211702,2-Diethoxy-N-(thiophen-2-ylmethylene)ethaneamine수율 93.5%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

2-Thiophene aldehyde (62.8 g) and 74.6 g of aminoacetaldehyde diethylacetal were dissolved in 200 mL of toluene and heated to reflux for 6 hours together with dehydration using a Dean-Stark trap. After confirming that a theoretical amount of water was separated, the solvent was evaporated therefrom in vacuo. The concentrated liquid was purified by a vacuum distillation to give 119 g of the objective compound.

후처리

  1. temperatureheated
  2. temperatureto reflux for 6 hours together with dehydration
  3. customwas separated
  4. customthe solvent was evaporated
  5. distillationThe concentrated liquid was purified by a vacuum distillation

출처 및 근거

ORD 기록
ord-25d264f5ee534d2cac39cbebe14254b6
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08217031B2

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