1,2-Dichloro-4-fluorobenzene → 7-(3,4-Dichlorophenyloxy)-5-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

HRID 1511620Notes

Reaction equation

HRID 1511620 reaction equation
[CH3:1][N:2]1[CH2:7][CH:6]([OH:8])[C:5]2[S:9][CH:10]=[CH:11][C:4]=2[CH2:3]1.[Cl:12][C:13]1[CH:14]=[C:15](F)[CH:16]=[CH:17][C:18]=1[Cl:19]>>[Cl:12][C:13]1[CH:14]=[C:15]([O:8][CH:6]2[CH2:7][N:2]([CH3:1])[CH2:3][C:4]3[CH:11]=[CH:10][S:9][C:5]2=3)[CH:16]=[CH:17][C:18]=1[Cl:19]

Participants

3

Reactant 2

HCID 740281,2-Dichloro-4-fluorobenzeneHCID 203668405-Methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-7-ol

Product 1

HCID 684131317-(3,4-Dichlorophenyloxy)-5-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

Procedure

The same method as in Example 1 was conducted using 5-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-7-ol (Reference Example 14) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3,4-dichloro-1-fluorobenzene instead of 1-fluoronaphthalene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-29225fbe417b41c5ae68c12e4d6c483c
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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