alpha,alpha,alpha,3-Tetrafluorotoluene → 5-Methyl-7-[3-(trifluoromethyl)phenyloxy]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

HRID 1511623Notes

Reaction equation

HRID 1511623 reaction equation
[CH3:1][N:2]1[CH2:7][CH:6]([OH:8])[C:5]2[S:9][CH:10]=[CH:11][C:4]=2[CH2:3]1.F[C:13]1[CH:14]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:16]=[CH:17][CH:18]=1>>[CH3:1][N:2]1[CH2:7][CH:6]([O:8][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=2)[C:5]2[S:9][CH:10]=[CH:11][C:4]=2[CH2:3]1

Participants

3

Reactant 2

HCID 67867alpha,alpha,alpha,3-TetrafluorotolueneHCID 203668405-Methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-7-ol

Product 1

HCID 687003605-Methyl-7-[3-(trifluoromethyl)phenyloxy]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

Procedure

The same method as in Example 1 was conducted using 5-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-7-ol (Reference Example 14) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3-fluorobenzo trifluoride instead of 1-fluoronaphthalene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-54fc97be02f0431ba4d7b490eb9e85e3
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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