Benzene, 1,2-dichloro-3-fluoro- → 4-(2,3-Dichlorophenyloxy)-6-methyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridine

HRID 1511624Notes

Reaction equation

HRID 1511624 reaction equation
[CH3:1][N:2]1[CH2:7][CH:6]([OH:8])[C:5]2[CH:9]=[CH:10][O:11][C:4]=2[CH2:3]1.[Cl:12][C:13]1[C:18]([Cl:19])=[CH:17][CH:16]=[CH:15][C:14]=1F>>[Cl:12][C:13]1[C:18]([Cl:19])=[CH:17][CH:16]=[CH:15][C:14]=1[O:8][CH:6]1[CH2:7][N:2]([CH3:1])[CH2:3][C:4]2[O:11][CH:10]=[CH:9][C:5]1=2

Participants

3

Reactant 2

HCID 119011Benzene, 1,2-dichloro-3-fluoro-HCID 133651566-Methyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-4-ol

Product 1

HCID 684111384-(2,3-Dichlorophenyloxy)-6-methyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridine

Procedure

The same method as in Example 1 was conducted using 6-methyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-4-ol (Reference Example 1) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 2,3-dichloro-1-fluorobenzene instead of 1-fluoronaphthalene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-e5b56f0a027d453d9a18082dc9df330f
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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