Benzene, 1,2-dichloro-3-fluoro- → HCID 68410092, compound

HRID 1511626Notes

Reaction equation

HRID 1511626 reaction equation
[CH2:1]([N:3]1[CH2:8][CH:7]([OH:9])[C:6]2[CH:10]=[CH:11][S:12][C:5]=2[CH2:4]1)[CH3:2].[Cl:13][C:14]1[C:19]([Cl:20])=[CH:18][CH:17]=[CH:16][C:15]=1F>>[ClH:13].[Cl:13][C:14]1[C:19]([Cl:20])=[CH:18][CH:17]=[CH:16][C:15]=1[O:9][CH:7]1[CH2:8][N:3]([CH2:1][CH3:2])[CH2:4][C:5]2[S:12][CH:11]=[CH:10][C:6]1=2

Participants

3

Reactant 2

HCID 119011Benzene, 1,2-dichloro-3-fluoro-HCID 68409987HCID 68409987, compound

Product 1

HCID 68410092HCID 68410092, compound

Procedure

The same method as in Example 3 was conducted using 6-ethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 7) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 2,3-dichloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-202f244db0ab43afaccc8fb1e5009992
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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