1,2-Dichloro-4-fluorobenzene → HCID 68410170, compound

HRID 1511627Notes

Reaction equation

HRID 1511627 reaction equation
[CH2:1]([N:3]1[CH2:8][CH:7]([OH:9])[C:6]2[CH:10]=[CH:11][S:12][C:5]=2[CH2:4]1)[CH3:2].[Cl:13][C:14]1[CH:15]=[C:16](F)[CH:17]=[CH:18][C:19]=1[Cl:20]>>[ClH:13].[Cl:13][C:14]1[CH:15]=[C:16]([O:9][CH:7]2[CH2:8][N:3]([CH2:1][CH3:2])[CH2:4][C:5]3[S:12][CH:11]=[CH:10][C:6]2=3)[CH:17]=[CH:18][C:19]=1[Cl:20]

Participants

3

Reactant 2

HCID 740281,2-Dichloro-4-fluorobenzeneHCID 68409987HCID 68409987, compound

Product 1

HCID 68410170HCID 68410170, compound

Procedure

The same method as in Example 3 was conducted using 6-ethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 7) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3,4-dichloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-6b2243fcff884da6b6e05c6d2e57a925
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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