1,2-Dichloro-4-fluorobenzene → HCID 68409993, compound

HRID 1511628Notes

Reaction equation

HRID 1511628 reaction equation
[CH:1]1([CH2:4][N:5]2[CH2:10][CH:9]([OH:11])[C:8]3[S:12][CH:13]=[CH:14][C:7]=3[CH2:6]2)[CH2:3][CH2:2]1.[Cl:15][C:16]1[CH:17]=[C:18](F)[CH:19]=[CH:20][C:21]=1[Cl:22]>>[Cl:15][C:16]1[CH:17]=[C:18]([O:11][CH:9]2[CH2:10][N:5]([CH2:4][CH:1]3[CH2:2][CH2:3]3)[CH2:6][C:7]3[CH:14]=[CH:13][S:12][C:8]2=3)[CH:19]=[CH:20][C:21]=1[Cl:22]

Participants

3

Reactant 2

HCID 740281,2-Dichloro-4-fluorobenzeneHCID 68410833HCID 68410833, compound

Product 1

HCID 68409993HCID 68409993, compound

Procedure

The same method as in Example 1 was conducted using 5-cyclopropylmethyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-7-ol (Reference Example 15) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3,4-dichloro-1-fluorobenzene instead of 1-fluoronaphthalene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-5a35ca9d24534be3af67b2a36d8a6275
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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