1,2-Dichloro-4-fluorobenzene → HCID 68412206, compound

HRID 1511630Notes

Reaction equation

HRID 1511630 reaction equation
[CH2:1]([N:4]1[CH2:9][CH:8]([OH:10])[C:7]2[S:11][CH:12]=[CH:13][C:6]=2[CH2:5]1)[CH:2]=[CH2:3].[Cl:14][C:15]1[CH:16]=[C:17](F)[CH:18]=[CH:19][C:20]=1[Cl:21]>>[ClH:14].[CH2:1]([N:4]1[CH2:9][CH:8]([O:10][C:18]2[CH:17]=[CH:16][C:15]([Cl:14])=[C:20]([Cl:21])[CH:19]=2)[C:7]2[S:11][CH:12]=[CH:13][C:6]=2[CH2:5]1)[CH:2]=[CH2:3]

Participants

3

Reactant 2

HCID 740281,2-Dichloro-4-fluorobenzeneHCID 68410185HCID 68410185, compound

Product 1

HCID 68412206HCID 68412206, compound

Procedure

The same method as in Example 3 was conducted using 5-allyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-7-ol (Reference Example 16) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3,4-dichloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-7b92f68b993a4c65bf0d3bb2faf6e41f
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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