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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1511631Generated: October 26, 2026

Benzene, 1,2-dichloro-3-fluoro- → 7-(2,3-Dichlorophenyloxy)-5-(2-fluoroethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

https://huagongshe.com/reaction/1511631

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzene, 1,2-dichloro-3-fluoro-HCID 119011—
Reactant5-(2-Fluoroethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-7-olHCID 86639228—
Product7-(2,3-Dichlorophenyloxy)-5-(2-fluoroethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridineHCID 86639227—

Reaction Steps

The same method as in Example 1 was conducted using 5-(2-fluoroethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-7-ol (Reference Example 17) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 2,3-dichloro-1-fluorobenzene instead of 1-fluoronaphthalene to give the objective compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08217031B2
Source datasetuspto-grants-2012_07
ORD IDord-b9a658db5e8640c29bc81b644334c5e9
Source noteuspto-grants-2012_07