1,2-Dichloro-4-fluorobenzene → HCID 68411029, compound

HRID 1511633Notes

Reaction equation

HRID 1511633 reaction equation
[S:1]1[C:9]2[CH:8]([OH:10])[CH2:7][NH:6][CH2:5][C:4]=2[CH:3]=[CH:2]1.[Cl:11][C:12]1[CH:13]=[C:14](F)[CH:15]=[CH:16][C:17]=1[Cl:18]>>[Cl:11][C:12]1[CH:13]=[C:14]([O:10][CH:8]2[CH2:7][NH:6][CH2:5][C:4]3[CH:3]=[CH:2][S:1][C:9]2=3)[CH:15]=[CH:16][C:17]=1[Cl:18]

Participants

3

Reactant 2

HCID 740281,2-Dichloro-4-fluorobenzeneHCID 123370154,5,6,7-Tetrahydrothieno[3,2-c]pyridin-7-ol

Product 1

HCID 68411029HCID 68411029, compound

Procedure

The same method as in Example 1 was conducted using 4,5,6,7-tetrahydrothieno[3,2-c]pyridin-7-ol (Reference Example 13) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3,4-dichloro-1-fluorobenzene instead of 1-fluoronaphthalene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-aaa254b70a9643ce92941e9578f629a2
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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