1-Bromo 4-fluoronaphthalene → HCID 68409721, compound

HRID 1511634Notes

Reaction equation

HRID 1511634 reaction equation
[S:1]1[C:9]2[CH:8]([OH:10])[CH2:7][NH:6][CH2:5][C:4]=2[CH:3]=[CH:2]1.[Br:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:15](F)=[CH:14][CH:13]=1>>[Br:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:15]([O:10][CH:8]2[CH2:7][NH:6][CH2:5][C:4]3[CH:3]=[CH:2][S:1][C:9]2=3)=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 676471-Bromo 4-fluoronaphthaleneHCID 123370154,5,6,7-Tetrahydrothieno[3,2-c]pyridin-7-ol

Product 1

HCID 68409721HCID 68409721, compound

Procedure

The same method as in Example 1 was conducted using 4,5,6,7-tetrahydrothieno[3,2-c]pyridin-7-ol (Reference Example 13) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 1-bromo-4-fluoronaphthalene instead of 1-fluoronaphthalene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-66c49bcee123413d85a0f1d84cdf3bf8
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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