1,2-Dichloro-4-fluorobenzene → HCID 68409684, compound

HRID 1511638Notes

Reaction equation

HRID 1511638 reaction equation
[Br:1][C:2]1[S:12][C:5]2[CH2:6][N:7]([CH3:11])[CH2:8][CH:9]([OH:10])[C:4]=2[CH:3]=1.[Cl:13][C:14]1[CH:15]=[C:16](F)[CH:17]=[CH:18][C:19]=1[Cl:20]>>[ClH:13].[Br:1][C:2]1[S:12][C:5]2[CH2:6][N:7]([CH3:11])[CH2:8][CH:9]([O:10][C:17]3[CH:16]=[CH:15][C:14]([Cl:13])=[C:19]([Cl:20])[CH:18]=3)[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 740281,2-Dichloro-4-fluorobenzeneHCID 68410544HCID 68410544, compound

Product 1

HCID 68409684HCID 68409684, compound

Procedure

The same method as in Example 3 was conducted using 2-bromo-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 12) instead of 6-methyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-4-ol (Reference Example 1) and was conducted using 3,4-dichloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-80d37546c86e47bab3d5479215eb98d6
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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