Benzene, 1,2-dichloro-3-fluoro- → HCID 68413383, compound

HRID 1511639Notes

Reaction equation

HRID 1511639 reaction equation
[CH3:1][C:2]1[S:11][C:5]2[CH2:6][NH:7][CH2:8][CH:9]([OH:10])[C:4]=2[CH:3]=1.[Cl:12][C:13]1[C:18]([Cl:19])=[CH:17][CH:16]=[CH:15][C:14]=1F>>[ClH:12].[Cl:12][C:13]1[C:18]([Cl:19])=[CH:17][CH:16]=[CH:15][C:14]=1[O:10][CH:9]1[CH2:8][NH:7][CH2:6][C:5]2[S:11][C:2]([CH3:1])=[CH:3][C:4]1=2

Participants

3

Reactant 2

HCID 119011Benzene, 1,2-dichloro-3-fluoro-HCID 20430562HCID 20430562, compound

Product 1

HCID 68413383HCID 68413383, compound

Procedure

The same method as in Example 3 was conducted using 2-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 8) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 2,3-dichloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-0af12c9c51c94202b4bc0c1ec1057b86
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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