1-Bromo-2-chloro-4-fluorobenzene → HCID 68426036, compound

HRID 1511641Notes

Reaction equation

HRID 1511641 reaction equation
[CH3:1][N:2]1[CH2:7][CH:6]([OH:8])[C:5]2[CH:9]=[CH:10][O:11][C:4]=2[CH2:3]1.[Br:12][C:13]1[CH:18]=[CH:17][C:16](F)=[CH:15][C:14]=1[Cl:20]>>[ClH:20].[Br:12][C:13]1[CH:18]=[CH:17][C:16]([O:8][CH:6]2[CH2:7][N:2]([CH3:1])[CH2:3][C:4]3[O:11][CH:10]=[CH:9][C:5]2=3)=[CH:15][C:14]=1[Cl:20]

Participants

3

Reactant 2

HCID 27334061-Bromo-2-chloro-4-fluorobenzeneHCID 133651566-Methyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-4-ol

Product 1

HCID 68426036HCID 68426036, compound

Procedure

The same method as in Example 3 was conducted using 6-methyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-4-ol (Reference Example 1) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 4-bromo-3-chloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-ccd1d5bd0a6c4a53bd902ff54648f590
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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