1,2-Dichloro-4-fluorobenzene → HCID 68412117, compound

HRID 1511645Notes

Reaction equation

HRID 1511645 reaction equation
[CH3:1][C:2]1[S:11][C:5]2[CH2:6][NH:7][CH2:8][CH:9]([OH:10])[C:4]=2[CH:3]=1.[Cl:12][C:13]1[CH:14]=[C:15](F)[CH:16]=[CH:17][C:18]=1[Cl:19]>>[ClH:12].[Cl:12][C:13]1[CH:14]=[C:15]([O:10][CH:9]2[CH2:8][NH:7][CH2:6][C:5]3[S:11][C:2]([CH3:1])=[CH:3][C:4]2=3)[CH:16]=[CH:17][C:18]=1[Cl:19]

Participants

3

Reactant 2

HCID 740281,2-Dichloro-4-fluorobenzeneHCID 20430562HCID 20430562, compound

Product 1

HCID 68412117HCID 68412117, compound

Procedure

The same method as in Example 3 was conducted using 2-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 8) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3,4-dichloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-bd9156cba5434d198d8339d0ab76a6a9
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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