4-Chloro-1-naphthol → HCID 68410836, compound

HRID 1511647Notes

Reaction equation

HRID 1511647 reaction equation
[CH3:1][C:2]1[O:12][C:5]2[CH2:6][N:7]([CH3:11])[CH2:8][CH:9]([OH:10])[C:4]=2[CH:3]=1.[Cl:13][C:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:17](O)=[CH:16][CH:15]=1>>[ClH:13].[Cl:13][C:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:17]([O:10][CH:9]2[CH2:8][N:7]([CH3:11])[CH2:6][C:5]3[O:12][C:2]([CH3:1])=[CH:3][C:4]2=3)=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 117874-Chloro-1-naphtholHCID 13365215HCID 13365215, compound

Product 1

HCID 68410836HCID 68410836, compound

Procedure

The same method as in Example 47 was conducted using 2,6-dimethyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-4-ol (Reference Example 2) instead of 6-methyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-4-ol (Reference Example 1) and was conducted using 4-chloro-1-naphthol instead of 4-chloro-3-methylphenol to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-31a24cd480a54edc9acc0094ee8ca390
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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