1,2-Dichloro-4-fluorobenzene → 4-(3,4-Dichlorophenyloxy)-7-methyl-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepine hydrochloride

HRID 1511649Notes

Reaction equation

HRID 1511649 reaction equation
[CH3:1][N:2]1[CH2:8][CH2:7][CH:6]([OH:9])[C:5]2[CH:10]=[CH:11][S:12][C:4]=2[CH2:3]1.[Cl:13][C:14]1[CH:15]=[C:16](F)[CH:17]=[CH:18][C:19]=1[Cl:20]>>[ClH:13].[Cl:13][C:14]1[CH:15]=[C:16]([O:9][CH:6]2[CH2:7][CH2:8][N:2]([CH3:1])[CH2:3][C:4]3[S:12][CH:11]=[CH:10][C:5]2=3)[CH:17]=[CH:18][C:19]=1[Cl:20]

Participants

3

Reactant 2

HCID 740281,2-Dichloro-4-fluorobenzeneHCID 684111377-methyl-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepin-4-ol

Product 1

HCID 684138664-(3,4-Dichlorophenyloxy)-7-methyl-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepine hydrochloride

Procedure

The same method as in Example 3 was conducted using 7-methyl-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepin-4-ol (Reference Example 22) instead of 6-methyl-5,6,7,8-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3,4-dichloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-d2517c69a3be4161adcf9578d2e9ebcb
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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