1,2-Dichloro-4-fluorobenzene → HCID 68412126, compound

HRID 1511651Notes

Reaction equation

HRID 1511651 reaction equation
[CH2:1]([N:3]1[CH2:8][CH:7]([OH:9])[C:6]2[CH:10]=[C:11]([CH3:13])[S:12][C:5]=2[CH2:4]1)[CH3:2].[Cl:14][C:15]1[CH:16]=[C:17](F)[CH:18]=[CH:19][C:20]=1[Cl:21]>>[ClH:14].[Cl:14][C:15]1[CH:16]=[C:17]([O:9][CH:7]2[CH2:8][N:3]([CH2:1][CH3:2])[CH2:4][C:5]3[S:12][C:11]([CH3:13])=[CH:10][C:6]2=3)[CH:18]=[CH:19][C:20]=1[Cl:21]

Participants

3

Reactant 2

HCID 740281,2-Dichloro-4-fluorobenzeneHCID 68409624HCID 68409624, compound

Product 1

HCID 68412126HCID 68412126, compound

Procedure

The same method as in Example 3 was conducted using 6-ethyl-2-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 10) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3,4-dichloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-da5fcafad59c45a189033676e454a000
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

Loading…