Benzene, 1,2-dichloro-3-fluoro- → HCID 68412482, compound

HRID 1511652Notes

Reaction equation

HRID 1511652 reaction equation
[CH2:1]([N:3]1[CH2:8][CH:7]([OH:9])[C:6]2[CH:10]=[C:11]([CH3:13])[S:12][C:5]=2[CH2:4]1)[CH3:2].[Cl:14][C:15]1[C:20]([Cl:21])=[CH:19][CH:18]=[CH:17][C:16]=1F>>[ClH:14].[Cl:14][C:15]1[C:20]([Cl:21])=[CH:19][CH:18]=[CH:17][C:16]=1[O:9][CH:7]1[CH2:8][N:3]([CH2:1][CH3:2])[CH2:4][C:5]2[S:12][C:11]([CH3:13])=[CH:10][C:6]1=2

Participants

3

Reactant 2

HCID 119011Benzene, 1,2-dichloro-3-fluoro-HCID 68409624HCID 68409624, compound

Product 1

HCID 68412482HCID 68412482, compound

Procedure

The same method as in Example 3 was conducted using 6-ethyl-2-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 10) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 2,3-dichloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-67c370e040fb49fba9677e3fb8998849
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

Loading…