1,2-Dichloro-4-fluorobenzene → HCID 68702955, compound

HRID 1511655Notes

Reaction equation

HRID 1511655 reaction equation
[Cl:1][C:2]1[S:13][C:5]2[CH2:6][N:7]([CH3:12])[CH2:8][CH2:9][CH:10]([OH:11])[C:4]=2[CH:3]=1.[Cl:14][C:15]1[CH:16]=[C:17](F)[CH:18]=[CH:19][C:20]=1[Cl:21]>>[ClH:1].[Cl:1][C:2]1[S:13][C:5]2[CH2:6][N:7]([CH3:12])[CH2:8][CH2:9][CH:10]([O:11][C:18]3[CH:17]=[CH:16][C:15]([Cl:14])=[C:20]([Cl:21])[CH:19]=3)[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 740281,2-Dichloro-4-fluorobenzeneHCID 68410743HCID 68410743, compound

Product 1

HCID 68702955HCID 68702955, compound

Procedure

The same method as in Example 3 was conducted using 2-chloro-7-methyl-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepin-4-ol (Reference Example 24) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3,4-dichloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-a91f75d9866b4f2e94201dc8201a6f74
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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