4-Fluorobenzamide → HCID 68413159, compound

HRID 1511659Notes

Reaction equation

HRID 1511659 reaction equation
[CH3:1][C:2]1[S:13][C:5]2[CH2:6][N:7]([CH3:12])[CH2:8][CH2:9][CH:10]([OH:11])[C:4]=2[CH:3]=1.F[C:15]1[CH:23]=[CH:22][C:18]([C:19]([NH2:21])=[O:20])=[CH:17][CH:16]=1>>[C:19]([C:18]1[CH:22]=[CH:23][C:15]([O:11][CH:10]2[CH2:9][CH2:8][N:7]([CH3:12])[CH2:6][C:5]3[S:13][C:2]([CH3:1])=[CH:3][C:4]2=3)=[CH:16][CH:17]=1)(=[O:20])[NH2:21]

Participants

3

Reactant 2

HCID 715724-FluorobenzamideHCID 684098842,7-dimethyl-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepin-4-ol

Product 1

HCID 68413159HCID 68413159, compound

Procedure

The same method as in Example 1 was conducted using 2,7-dimethyl-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepin-4-ol (Reference Example 23) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 4-fluorobenzamide instead of 1-fluoronaphthalene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-144ae8db1ab641c6bd1f91c64f015976
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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