1,2-Dichloro-4-fluorobenzene → HCID 68410874, compound

HRID 1511661Notes

Reaction equation

HRID 1511661 reaction equation
[O:1]1[C:5]2[CH2:6][NH:7][CH2:8][CH:9]([OH:10])[C:4]=2[CH:3]=[CH:2]1.[Cl:11][C:12]1[CH:13]=[C:14](F)[CH:15]=[CH:16][C:17]=1[Cl:18]>>[ClH:11].[Cl:11][C:12]1[CH:13]=[C:14]([O:10][CH:9]2[CH2:8][NH:7][CH2:6][C:5]3[O:1][CH:2]=[CH:3][C:4]2=3)[CH:15]=[CH:16][C:17]=1[Cl:18]

Participants

3

Reactant 2

HCID 740281,2-Dichloro-4-fluorobenzeneHCID 55300160HCID 55300160, compound

Product 1

HCID 68410874HCID 68410874, compound

Procedure

The same method as in Example 3 was conducted using 4,5,6,7-tetrahydrofuro[2,3-c]pyridin-4-ol (Reference Example 4) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3,4-dichloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-d6cf941b17c14c5f9b4dfd52cd62a3ba
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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