1,2-Dichloro-4-fluorobenzene → HCID 68411746, compound

HRID 1511663Notes

Reaction equation

HRID 1511663 reaction equation
[CH3:1][C:2]1[O:13][C:5]2[CH2:6][CH2:7][N:8]([CH3:12])[CH2:9][CH:10]([OH:11])[C:4]=2[CH:3]=1.[Cl:14][C:15]1[CH:16]=[C:17](F)[CH:18]=[CH:19][C:20]=1[Cl:21]>>[Cl:14][C:15]1[CH:16]=[C:17]([O:11][CH:10]2[CH2:9][N:8]([CH3:12])[CH2:7][CH2:6][C:5]3[O:13][C:2]([CH3:1])=[CH:3][C:4]2=3)[CH:18]=[CH:19][C:20]=1[Cl:21]

Participants

3

Reactant 2

HCID 740281,2-Dichloro-4-fluorobenzeneHCID 68409883HCID 68409883, compound

Product 1

HCID 68411746HCID 68411746, compound

Procedure

The same method as in Example 1 was conducted using 2,6-dimethyl-5,6,7,8-tetrahydro-4H-furo[2,3-d]azepin-4-ol (Reference Example 26) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3,4-dichloro-1-fluorobenzene instead of 1-fluoronaphthalene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-4007a0e2f4954f37a484129614834ad5
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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