2-Chloro-4-fluoro-1-(trifluoromethyl)benzene → HCID 68411815, compound

HRID 1511671Notes

Reaction equation

HRID 1511671 reaction equation
[CH3:1][N:2]1[CH2:8][CH:7]([OH:9])[C:6]2[CH:10]=[CH:11][S:12][C:5]=2[CH2:4][CH2:3]1.[Cl:13][C:14]1[CH:19]=[C:18](F)[CH:17]=[CH:16][C:15]=1[C:21]([F:24])([F:23])[F:22]>>[ClH:13].[Cl:13][C:14]1[CH:19]=[C:18]([O:9][CH:7]2[CH2:8][N:2]([CH3:1])[CH2:3][CH2:4][C:5]3[S:12][CH:11]=[CH:10][C:6]2=3)[CH:17]=[CH:16][C:15]=1[C:21]([F:22])([F:23])[F:24]

Participants

3

Reactant 2

HCID 232358632-Chloro-4-fluoro-1-(trifluoromethyl)benzeneHCID 68409998HCID 68409998, compound

Product 1

HCID 68411815HCID 68411815, compound

Procedure

The same method as in Example 3 was conducted using 6-methyl-5,6,7,8-tetrahydro-4H-thieno[2,3-d]azepin-4-ol (Reference Example 28) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 2-chloro-4-fluorobenzotrifluoride instead of 1,3-difluorobenzene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-6c17620b70d542a4a11e9f697cd046a9
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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