HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-Chloro-3-fluoro-2-(trifluoromethyl)benzene → 4-[3-Chloro-2-(trifluoromethyl)phenyloxy]-6-methyl-5,6,7,8-tetrahydro-4H-thien o[2,3-d]azepine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-Chloro-3-fluoro-2-(trifluoromethyl)benzene | HCID 16743980 | — |
| Edukt | 6-methyl-5,6,7,8-tetrahydro-4H-thieno[2,3-d]azepin-4-ol | HCID 68409998 | — |
| Produkt | 4-[3-Chloro-2-(trifluoromethyl)phenyloxy]-6-methyl-5,6,7,8-tetrahydro-4H-thien o[2,3-d]azepine | HCID 68413205 | — |
Reaktionsschritte
The same method as in Example 1 was conducted using 6-methyl-5,6,7,8-tetrahydro-4H-thieno[2,3-d]azepin-4-ol (Reference Example 28) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 2-chloro-6-fluorobenzotrifluoride instead of 1-fluoronaphthalene to give the objective compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08217031B2 |
| Quelldatensatz | uspto-grants-2012_07 |
| ORD ID | ord-bf4c692414174be0a276a7f194dc085b |
| Quellennotiz | uspto-grants-2012_07 |