5-Bromo-2-fluorobenzotrifluoride → HCID 68411171, compound

HRID 1511674Notes

Reaction equation

HRID 1511674 reaction equation
[O:1]1[C:5]2[CH2:6][NH:7][CH2:8][CH:9]([OH:10])[C:4]=2[CH:3]=[CH:2]1.[Br:11][C:12]1[CH:13]=[CH:14][C:15](F)=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:17]=1>>[Br:11][C:12]1[CH:13]=[CH:14][C:15]([O:10][CH:9]2[CH2:8][NH:7][CH2:6][C:5]3[O:1][CH:2]=[CH:3][C:4]2=3)=[C:16]([C:18]([F:19])([F:20])[F:21])[CH:17]=1

Participants

3

Reactant 2

HCID 27363255-Bromo-2-fluorobenzotrifluorideHCID 55300160HCID 55300160, compound

Product 1

HCID 68411171HCID 68411171, compound

Procedure

The same method as in Example 1 was conducted using 4,5,6,7-tetrahydrofuro[2,3-c]pyridin-4-ol (Reference Example 4) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 5-bromo-2-fluorobenzotrifluoride instead of 1-fluoronaphthalene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-f7fccf0176374b6a879cec767a9dfbe9
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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