HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene, 1,2-dichloro-3-fluoro- → 4-(2,3-Dichlorophenyloxy)-7-methyl-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene, 1,2-dichloro-3-fluoro- | HCID 119011 | — |
| Reactant | 7-methyl-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepin-4-ol | HCID 68411137 | — |
| Product | 4-(2,3-Dichlorophenyloxy)-7-methyl-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepine hydrochloride | HCID 68425694 | — |
Reaction Steps
The same method as in Example 3 was conducted using 7-methyl-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepin-4-ol (Reference Example 22) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 2,3-dichloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08217031B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-2f33857fe6c24d4788f0e42dd34f4abe |
| Source note | uspto-grants-2012_07 |