Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1511677Generated: November 4, 2026

Benzene, 1,2-dichloro-3-fluoro- → 4-(2,3-Dichlorophenyloxy)-7-methyl-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepine hydrochloride

https://huagongshe.com/reaction/1511677

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzene, 1,2-dichloro-3-fluoro-HCID 119011—
Reactant7-methyl-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepin-4-olHCID 68411137—
Product4-(2,3-Dichlorophenyloxy)-7-methyl-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepine hydrochlorideHCID 68425694—

Reaction Steps

The same method as in Example 3 was conducted using 7-methyl-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepin-4-ol (Reference Example 22) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 2,3-dichloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08217031B2
Source datasetuspto-grants-2012_07
ORD IDord-2f33857fe6c24d4788f0e42dd34f4abe
Source noteuspto-grants-2012_07