2-Fluoronaphthalene → 2,7-Dimethyl-4-(naphthalen-2-yloxy)-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepine

HRID 1511678Notes

Reaction equation

[CH3:1][C:2]1[S:13][C:5]2[CH2:6][N:7]([CH3:12])[CH2:8][CH2:9][CH:10]([OH:11])[C:4]=2[CH:3]=1.F[C:15]1[CH:24]=[CH:23][C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=1>>[CH3:1][C:2]1[S:13][C:5]2[CH2:6][N:7]([CH3:12])[CH2:8][CH2:9][CH:10]([O:11][C:15]3[CH:24]=[CH:23][C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[CH:16]=3)[C:4]=2[CH:3]=1

Participants

Reactant 2

HCID 675832-Fluoronaphthalene

HCID 684098842,7-dimethyl-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepin-4-ol

Product 1

HCID 684117412,7-Dimethyl-4-(naphthalen-2-yloxy)-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepine

Procedure

The same method as in Example 1 was conducted using 2,7-dimethyl-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepin-4-ol (Reference Example 23) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 2-fluoronaphthalene instead of 1-fluoronaphthalene to give the objective compound.

Workup

customto give the objective compound

Sources & evidence

ORD record: ord-aadc6cfb37844895a0c1d0eb5f9939d3
Source dataset: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08217031B2

Reaction notes

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