1-Bromo-2-chloro-3-fluorobenzene → HCID 68410782, compound

HRID 1511679Notes

Reaction equation

HRID 1511679 reaction equation
[CH3:1][N:2]1[CH2:7][CH:6]([OH:8])[C:5]2[CH:9]=[CH:10][O:11][C:4]=2[CH2:3]1.[Br:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15](F)[C:14]=1[Cl:20]>>[ClH:20].[Br:12][C:13]1[C:14]([Cl:20])=[C:15]([O:8][CH:6]2[CH2:7][N:2]([CH3:1])[CH2:3][C:4]3[O:11][CH:10]=[CH:9][C:5]2=3)[CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 37393011-Bromo-2-chloro-3-fluorobenzeneHCID 133651566-Methyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-4-ol

Product 1

HCID 68410782HCID 68410782, compound

Procedure

The same method as in Example 1 was conducted using 6-methyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-4-ol (Reference Example 1) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 1-bromo-2-chloro-3-fluorobenzene instead of 1-fluoronaphthalene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-4c34cf02335d4b63b6a8e8edaed2de6a
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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