1,2-Dibromo-4-fluorobenzene → 8-(3,4-Dibromophenyloxy)-5-methyl-5,6,7,8-tetrahydro-4H-furo[3,2-c]azepine

HRID 1511684Notes

Reaction equation

HRID 1511684 reaction equation
[CH3:1][N:2]1[CH2:8][CH2:7][CH:6]([OH:9])[C:5]2[O:10][CH:11]=[CH:12][C:4]=2[CH2:3]1.[Br:13][C:14]1[CH:15]=[C:16](F)[CH:17]=[CH:18][C:19]=1[Br:20]>>[Br:13][C:14]1[CH:15]=[C:16]([O:9][CH:6]2[CH2:7][CH2:8][N:2]([CH3:1])[CH2:3][C:4]3[CH:12]=[CH:11][O:10][C:5]2=3)[CH:17]=[CH:18][C:19]=1[Br:20]

Participants

3

Reactant 2

HCID 754021,2-Dibromo-4-fluorobenzeneHCID 684099105-methyl-5,6,7,8-tetrahydro-4H-furo[3,2-c]azepin-8-ol

Product 1

HCID 684099358-(3,4-Dibromophenyloxy)-5-methyl-5,6,7,8-tetrahydro-4H-furo[3,2-c]azepine

Procedure

The same method as in Example 1 was conducted using 5-methyl-5,6,7,8-tetrahydro-4H-furo[3,2-c]azepin-8-ol (Reference Example 21) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3,4-dibromo-1-fluorobenzene instead of 1-fluoronaphthalene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-38817c8816e94ecd9e2fb7514fb83920
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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