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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1511685Generated: October 26, 2026

1-Bromo 4-fluoronaphthalene → 8-(4-Bromonaphthalen-1-yloxy)-5-methyl-5,6,7,8-tetrahydro-4H-furo[3,2-c]azepine

https://huagongshe.com/reaction/1511685

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo 4-fluoronaphthaleneHCID 67647—
Reactant5-methyl-5,6,7,8-tetrahydro-4H-furo[3,2-c]azepin-8-olHCID 68409910—
Product8-(4-Bromonaphthalen-1-yloxy)-5-methyl-5,6,7,8-tetrahydro-4H-furo[3,2-c]azepineHCID 68411554—

Reaction Steps

The same method as in Example 1 was conducted using 5-methyl-5,6,7,8-tetrahydro-4H-furo[3,2-c]azepin-8-ol (Reference Example 21) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 1-bromo-4-fluoronaphthalene instead of 1-fluoronaphthalene to give the objective compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08217031B2
Source datasetuspto-grants-2012_07
ORD IDord-5dc442aa96c64b49974efe6cfeb198a5
Source noteuspto-grants-2012_07