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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1511686Generated: October 26, 2026

Benzene, 1,2-dichloro-3-fluoro- → 4-(2,3-Dichlorophenyloxy)-2,7-dimethyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepine

https://huagongshe.com/reaction/1511686

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzene, 1,2-dichloro-3-fluoro-HCID 119011—
Reactant2,7-dimethyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-olHCID 68410119—
Product4-(2,3-Dichlorophenyloxy)-2,7-dimethyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepineHCID 25027798—

Reaction Steps

The same method as in Example 1 was conducted using 2,7-dimethyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol (Reference Example 20) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 2,3-dichloro-1-fluorobenzene instead of 1-fluoronaphthalene to give the objective compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08217031B2
Source datasetuspto-grants-2012_07
ORD IDord-3890b5173e2847ddb4cd154cb6cc21fb
Source noteuspto-grants-2012_07