Benzene, 1-fluoro-4-(trifluoromethyl)- → 5-Methyl-8-[4-(trifluoromethyl)phenyloxy]-5,6,7,8-tetrahydro-4h-furo[3,2-c]azepine

HRID 1511687Notes

Reaction equation

HRID 1511687 reaction equation
[CH3:1][N:2]1[CH2:8][CH2:7][CH:6]([OH:9])[C:5]2[O:10][CH:11]=[CH:12][C:4]=2[CH2:3]1.F[C:14]1[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=1>>[CH3:1][N:2]1[CH2:8][CH2:7][CH:6]([O:9][C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)[C:5]2[O:10][CH:11]=[CH:12][C:4]=2[CH2:3]1

Participants

3

Reactant 2

HCID 67873Benzene, 1-fluoro-4-(trifluoromethyl)-HCID 684099105-methyl-5,6,7,8-tetrahydro-4H-furo[3,2-c]azepin-8-ol

Product 1

HCID 684119005-Methyl-8-[4-(trifluoromethyl)phenyloxy]-5,6,7,8-tetrahydro-4h-furo[3,2-c]azepine

Procedure

The same method as in Example 1 was conducted using 5-methyl-5,6,7,8-tetrahydro-4H-furo[3,2-c]azepin-8-ol (Reference Example 21) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 4-fluorobenzotrifluoride instead of 1-fluoronaphthalene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-a1dcf0a0dd634849abf573a1de778551
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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