1-Bromo 4-fluoronaphthalene → HCID 68410460, Verbindung

HRID 1511690Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1511690
[CH3:1][N:2]1[CH2:8][CH2:7][CH:6]([OH:9])[C:5]2[CH:10]=[CH:11][O:12][C:4]=2[CH2:3]1.[Br:13][C:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:17](F)=[CH:16][CH:15]=1>>[Br:13][C:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:17]([O:9][CH:6]2[CH2:7][CH2:8][N:2]([CH3:1])[CH2:3][C:4]3[O:12][CH:11]=[CH:10][C:5]2=3)=[CH:16][CH:15]=1

Komponenten

3

Edukt 2

HCID 676471-Bromo 4-fluoronaphthaleneHCID 684096967-Methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol

Produkt 1

HCID 68410460HCID 68410460, Verbindung

Versuchsvorschrift

The same method as in Example 1 was conducted using 7-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol (Reference Example 19) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 1-bromo-4-fluoronaphthalene instead of 1-fluoronaphthalene to give the objective compound.

Aufarbeitung

  1. customto give the objective compound

Quellen und Nachweise

ORD-Eintrag
ord-fd629b53726241bda8963a7aefce2448
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08217031B2

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