1-Bromo-2-chloro-3-fluorobenzene → 4-(3-Bromo-2-chlorophenyloxy)-2-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepine hydrochloride

HRID 1511710Notes

Reaction equation

HRID 1511710 reaction equation
[CH3:1][C:2]1[O:12][C:5]2[CH2:6][NH:7][CH2:8][CH2:9][CH:10]([OH:11])[C:4]=2[CH:3]=1.[Br:13][C:14]1[C:15]([Cl:21])=[C:16](F)[CH:17]=[CH:18][CH:19]=1>>[ClH:21].[Br:13][C:14]1[C:15]([Cl:21])=[C:16]([O:11][CH:10]2[CH2:9][CH2:8][NH:7][CH2:6][C:5]3[O:12][C:2]([CH3:1])=[CH:3][C:4]2=3)[CH:17]=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 37393011-Bromo-2-chloro-3-fluorobenzeneHCID 684100692-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol

Product 1

HCID 684118044-(3-Bromo-2-chlorophenyloxy)-2-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepine hydrochloride

Procedure

The same method as in Example 3 was conducted using 2-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol (Reference Example 44) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3-bromo-2-chloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-83b72abe7f2f4526990c612e8e381898
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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