Citric Acid → HCID 68411512, compound

HRID 1511713Notes

Reaction equation

HRID 1511713 reaction equation
[CH3:1][N:2]1[CH2:8][CH2:7][CH:6]([O:9][C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH:13]=[CH:12][CH:11]=2)[C:5]2[O:20][CH:21]=[CH:22][C:4]=2[CH2:3]1.[C:23]([OH:35])(=[O:34])[CH2:24][C:25]([CH2:30][C:31]([OH:33])=[O:32])([C:27]([OH:29])=[O:28])[OH:26]>CO>[C:23]([OH:35])(=[O:34])[CH2:24][C:25]([CH2:30][C:31]([OH:33])=[O:32])([C:27]([OH:29])=[O:28])[OH:26].[CH3:1][N:2]1[CH2:8][CH2:7][CH:6]([O:9][C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH:13]=[CH:12][CH:11]=2)[C:5]2[O:20][CH:21]=[CH:22][C:4]=2[CH2:3]1

Participants

4

Reactant 2

HCID 311Citric AcidHCID 25027797HCID 25027797, compound

Product 1

HCID 68411512HCID 68411512, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The free body of 5-methyl-8-(naphthalen-1-yloxy)-5,6,7,8-tetrahydro-4H-furo[3,2-c]azepine provided with Example 157 was dissolved in methanol, and then into the resulting methanol solution was added 1 equivalent of citric acid and was stirred for 1 hour.

Sources & evidence

ORD record
ord-7293c5a5e2b04d39962953468fac5576
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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