3-Chloro-4-fluorobenzonitrile → HCID 68411225, compound

HRID 1511715Notes

Reaction equation

HRID 1511715 reaction equation
[CH3:1][N:2]1[CH2:8][CH2:7][CH:6]([OH:9])[C:5]2[CH:10]=[CH:11][O:12][C:4]=2[CH2:3]1.[Cl:13][C:14]1[CH:15]=[C:16]([CH:19]=[CH:20][C:21]=1F)[C:17]#[N:18]>>[ClH:13].[Cl:13][C:14]1[CH:15]=[C:16]([C:17]#[N:18])[CH:19]=[CH:20][C:21]=1[O:9][CH:6]1[CH2:7][CH2:8][N:2]([CH3:1])[CH2:3][C:4]2[O:12][CH:11]=[CH:10][C:5]1=2

Participants

3

Reactant 2

HCID 1455253-Chloro-4-fluorobenzonitrileHCID 684096967-Methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol

Product 1

HCID 68411225HCID 68411225, compound

Procedure

The same method as in Example 3 was conducted using 7-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol (Reference Example 19) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3-chloro-4-fluorobenzonitrile instead of 1,3-difluorobenzene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-90212ccc97834b9aa9f4575fb1b44035
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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