3-Chloro-4-fluorobenzamide → 4-(4-Carbamoyl-2-chlorophenyloxy)-2,7-dimethyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepine hydrochloride

HRID 1511723ノート

反応式

HRID 1511723 の反応式
[CH3:1][C:2]1[O:13][C:5]2[CH2:6][N:7]([CH3:12])[CH2:8][CH2:9][CH:10]([OH:11])[C:4]=2[CH:3]=1.[C:14]([C:17]1[CH:22]=[CH:21][C:20](F)=[C:19]([Cl:24])[CH:18]=1)(=[O:16])[NH2:15]>>[ClH:24].[C:14]([C:17]1[CH:22]=[CH:21][C:20]([O:11][CH:10]2[CH2:9][CH2:8][N:7]([CH3:12])[CH2:6][C:5]3[O:13][C:2]([CH3:1])=[CH:3][C:4]2=3)=[C:19]([Cl:24])[CH:18]=1)(=[O:16])[NH2:15]

参加物

3

反応物 2

HCID 27365203-Chloro-4-fluorobenzamideHCID 684101192,7-dimethyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol

生成物 1

HCID 684101774-(4-Carbamoyl-2-chlorophenyloxy)-2,7-dimethyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepine hydrochloride

実験手順

The same method as in Example 3 was conducted using 2,7-dimethyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol (Reference Example 20) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 4-carbamoyl-2-chloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

後処理

  1. customto give the objective compound

出典と根拠

ORDレコード
ord-0da993279fc44375a87913b7ff6179d2
出典データセット
uspto-grants-2012_07
特許番号
US08217031B2

反応ノート

読み込み中…