HCID 57234037, compound → HCID 68423375, compound

HRID 1511726Notes

Reaction equation

HRID 1511726 reaction equation
[CH3:1][N:2]1[CH2:8][CH2:7][CH:6]([OH:9])[C:5]2[CH:10]=[CH:11][O:12][C:4]=2[CH2:3]1.[CH3:13][N:14]([CH3:25])[C:15]([C:17]1[C:18]([Cl:24])=[C:19](F)[CH:20]=[CH:21][CH:22]=1)=[O:16]>>[ClH:24].[CH3:13][N:14]([CH3:25])[C:15]([C:17]1[C:18]([Cl:24])=[C:19]([O:9][CH:6]2[CH2:7][CH2:8][N:2]([CH3:1])[CH2:3][C:4]3[O:12][CH:11]=[CH:10][C:5]2=3)[CH:20]=[CH:21][CH:22]=1)=[O:16]

Participants

3

Reactant 2

HCID 57234037HCID 57234037, compoundHCID 684096967-Methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol

Product 1

HCID 68423375HCID 68423375, compound

Procedure

The same method as in Example 3 was conducted using 7-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol (Reference Example 19) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3-dimethylcarbamoyl-2-chloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-f91e382dbe9b41da87a6d5fc8478cad0
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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